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Search Results to Charles A Dinarello

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One or more keywords matched the following items that are connected to Dinarello, Charles

Item TypeName
Academic Article Cross-linking of the beta-glucan receptor on human monocytes results in interleukin-1 receptor antagonist but not interleukin-1 production.
Academic Article Cytokines in acute myocardial infarction: selective increase in circulating tumor necrosis factor, its soluble receptor, and interleukin-1 receptor antagonist.
Academic Article Genetic susceptibility markers in Danish patients with type 1 (insulin-dependent) diabetes--evidence for polygenicity in man. Danish Study Group of Diabetes in Childhood.
Academic Article Interleukin-1 receptor antagonist suppresses contact hypersensitivity.
Academic Article Antiinflammatory properties of hepatic acute phase proteins: preferential induction of interleukin 1 (IL-1) receptor antagonist over IL-1 beta synthesis by human peripheral blood mononuclear cells.
Academic Article Cytokines in human renal interstitial fibrosis. I. Interleukin-1 is a paracrine growth factor for cultured fibrosis-derived kidney fibroblasts.
Academic Article Cytokines in human renal interstitial fibrosis. II. Intrinsic interleukin (IL)-1 synthesis and IL-1-dependent production of IL-6 and IL-8 by cultured kidney fibroblasts.
Academic Article Balance of IL-1 receptor antagonist/IL-1 beta in rheumatoid synovium and its regulation by IL-4 and IL-10.
Academic Article Blocking interleukin-1 receptors.
Academic Article Differential gene expression for IL-1 receptor antagonist, IL-1, and TNF receptors and IL-1 and TNF synthesis may explain IL-1-induced resistance to infection.
Academic Article Induction of circulating soluble tumour necrosis factor receptor and interleukin 1 receptor antagonist following interleukin 1 alpha infusion in humans.
Academic Article Interleukin-1 favours the in vitro development of type 2 T helper (Th2) human T-cell clones.
Academic Article Circulating interleukin-1 receptor antagonist concentrations are increased in adult patients with thermal injury.
Academic Article Induction of circulating antagonists to IL-1 and TNF by IL-2 administration and their effects on IL-2 induced cytokine production in vitro.
Academic Article Interleukin-1.
Academic Article Circulating interleukin-1 and tumor necrosis factor antagonists in liver disease.
Academic Article Interleukin-1 receptor blockade reduces the number and size of murine B16 melanoma hepatic metastases.
Academic Article Gender differences in IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist secretion from mononuclear cells and urinary excretion.
Academic Article Modalities for reducing interleukin 1 activity in disease.
Academic Article Histamine enhances interleukin (IL)-1-induced IL-1 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells. Comparison with IL-1 receptor antagonist.
Academic Article Induction of circulating and erythrocyte-bound IL-8 by IL-2 immunotherapy and suppression of its in vitro production by IL-1 receptor antagonist and soluble tumor necrosis factor receptor (p75) chimera.
Academic Article Interleukin-1 and tumor necrosis factor and their naturally occurring antagonists during hemodialysis.
Academic Article Intestinal production of interleukin-1 alpha during endotoxemia in the mouse.
Academic Article The role of interleukin-1 in host responses to infectious diseases.
Academic Article Anticytokine strategies in the treatment of the systemic inflammatory response syndrome.
Academic Article Induction of circulating IL-1 receptor antagonist by IFN treatment.
Academic Article Interleukin 1 induces HIV-1 expression in chronically infected U1 cells: blockade by interleukin 1 receptor antagonist and tumor necrosis factor binding protein type 1.
Academic Article Interleukin-13 (IL-13) induces IL-1 receptor antagonist gene expression and protein synthesis in peripheral blood mononuclear cells: inhibition by an IL-4 mutant protein.
Academic Article Interleukin-1 receptor antagonist inhibits subcutaneous B16 melanoma growth in vivo.
Academic Article The interleukin-1 receptor antagonist can either reduce or enhance the lethality of Klebsiella pneumoniae sepsis in newborn rats.
Academic Article Expression of interleukin-1 receptor antagonist (IL-1ra) by human circulating polymorphonuclear cells.
Academic Article Modulation of osteoclast-activating factor activity of multiple myeloma bone marrow cells by different interleukin-1 inhibitors.
Academic Article Cytokines as mediators in the pathogenesis of septic shock.
Academic Article Interleukin 1 (IL-1)-dependent melanoma hepatic metastasis in vivo; increased endothelial adherence by IL-1-induced mannose receptors and growth factor production in vitro.
Academic Article Interleukin-1 and interleukin-1 receptor antagonist.
Academic Article Pharmacokinetics, safety and immunomodulatory effects of human recombinant interleukin-1 receptor antagonist in healthy humans.
Academic Article Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells.
Academic Article Correlation of serum levels of interleukin-1 family members with disease activity and response to treatment in hairy cell leukemia.
Academic Article Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist.
Academic Article Modulation of acute myeloblastic leukemia (AML) cell proliferation and blast colony formation by antisense oligomer for IL-1 beta converting enzyme (ICE) and IL-1 receptor antagonist (IL-1ra).
Academic Article The association of peripheral monocyte derived interleukin 1beta (IL-1beta), IL-1 receptor antagonist, and tumor necrosis factor-alpha with osteoarthritis in the elderly.
Academic Article [Antagonists in neonatal sepsis].
Academic Article A randomized, controlled trial of IL-10 in humans. Inhibition of inflammatory cytokine production and immune responses.
Academic Article Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: I. IL-1 receptor antagonist inhibits IL-1-induced cytokine synthesis and blocks the binding of IL-1 to its type II receptor on human monocytes.
Academic Article Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: II. IL-1 receptor antagonist inhibits lipopolysaccharide-induced cytokine synthesis by human monocytes.
Academic Article Monokine antagonism is reduced in patients with IDDM.
Academic Article Involvement of interleukin 1 and interleukin 1 antagonist in pancreatic beta-cell destruction in insulin-dependent diabetes mellitus.
Academic Article Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55.
Academic Article Interleukin-1 (IL-1) receptor antagonist prevents Staphylococcus epidermidis-induced hypotension and reduces circulating levels of tumor necrosis factor and IL-1 beta in rabbits.
Academic Article Modulation of cell proliferation and cytokine production in AML by recombinant interleukin-1 receptor antagonist.
Academic Article IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor.
Academic Article Elaboration of interleukin 1-receptor antagonist is not attenuated by glucocorticoids after endotoxemia.
Academic Article Activated platelets induce endothelial secretion of interleukin-8 in vitro via an interleukin-1-mediated event.
Academic Article Biologic basis for interleukin-1 in disease.
Academic Article Tumor necrosis factor (TNF)-alpha-induced interleukin-8 in human blood cultures discriminates neutralization by the p55 and p75 TNF soluble receptors.
Academic Article Live Borrelia burgdorferi preferentially activate interleukin-1 beta gene expression and protein synthesis over the interleukin-1 receptor antagonist.
Academic Article IL-1 regulates in vivo C-X-C chemokine induction and neutrophil sequestration following endotoxemia.
Academic Article The pattern of interleukin-1beta (IL-1beta) and its modulating agents IL-1 receptor antagonist and IL-1 soluble receptor type II in acute meningococcal infections.
Academic Article Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: low doses stimulate hepatic triglyceride production while high doses inhibit clearance.
Academic Article A specific receptor antagonist for interleukin 1 prevents Escherichia coli-induced shock in rabbits.
Academic Article Peripheral nerve regeneration is impeded by interleukin-1 receptor antagonist released from a polymeric guidance channel.
Academic Article Enhancement of growth of virulent strains of Escherichia coli by interleukin-1.
Academic Article Modulation of cell proliferation and cytokine production in acute myeloblastic leukemia by interleukin-1 receptor antagonist and lack of its expression by leukemic cells.
Academic Article A continuous delivery system of IL-1 receptor antagonist reduces angiogenesis and inhibits tumor development.
Academic Article Interleukin-1 receptor antagonist circulates in experimental inflammation and in human disease.
Academic Article Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro.
Academic Article Increasing levels of interleukin (IL)-1Ra and IL-6 during the first 2 days of hospitalization in unstable angina are associated with increased risk of in-hospital coronary events.
Academic Article Blocking IL-1 in systemic inflammation.
Academic Article Rapid responses to anakinra in patients with refractory adult-onset Still's disease.
Academic Article Sustained delivery of IL-1 Ra from biodegradable microspheres reduces the number of murine B16 melanoma lung metastases.
Academic Article Resistant Beh?et disease responsive to anakinra.
Academic Article Targeting the pathogenic role of interleukin 1{beta} in the progression of smoldering/indolent myeloma to active disease.
Academic Article Alpha-1-antitrypsin is an endogenous inhibitor of proinflammatory cytokine production in whole blood.
Academic Article Adult-onset Still's disease with myocarditis successfully treated with the interleukin-1 receptor antagonist anakinra.
Academic Article Anakinra for the inflammatory complications of chronic granulomatous disease.
Academic Article Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1beta.
Academic Article Production of interleukin-1-receptor antagonist during experimental endotoxaemia.
Academic Article Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1a.
Academic Article Reduced mitogen stimulation of DNA synthesis in human lymphocytes by a human recombinant interleukin-1 receptor antagonist.
Academic Article Production of interleukin-1 receptor antagonist and interleukin-1 beta by peripheral blood mononuclear cells is differentially regulated.
Academic Article Interleukin-1 and interleukin-1 receptor antagonist production during haemodialysis: which cytokine is a surrogate marker for dialysis-related complications?
Academic Article Is there a role for interleukin-1 blockade in intravenous immunoglobulin therapy?
Academic Article Interleukin-1 receptor antagonist: an index of dialysis-induced interleukin-1 production.
Academic Article Interleukin-1 receptor antagonist transiently impairs antibacterial defense but not survival in murine pneumococcal pneumonia.
Academic Article Interleukin-1 induces interleukin-8 secretion from endothelial cells by a juxtacrine mechanism.
Academic Article The precursor form of IL-1alpha is an intracrine proinflammatory activator of transcription.
Academic Article Plasma levels of IL-1 beta, TNF alpha and their specific inhibitors in undialyzed chronic renal failure, CAPD and hemodialysis patients.
Academic Article Suppression of juvenile chronic myelogenous leukemia colony growth by interleukin-1 receptor antagonist.
Academic Article High cytokine levels at admission are associated with fatal outcome in patients with necrotizing fasciitis.
Academic Article Synthesis of tumor necrosis factor alpha and interleukin-1 receptor antagonist, but not interleukin-1, by human mononuclear cells is enhanced by exposure of whole blood to shear stress.
Academic Article Lipopolysaccharide induces human interleukin-1 receptor antagonist and interleukin-1 production in the same cell.
Academic Article Induction of interleukin-1 and interleukin-1 receptor antagonist.
Academic Article Physiological and cytokine responses in IL-1 beta-deficient mice after zymosan-induced inflammation.
Academic Article Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice.
Academic Article The many worlds of reducing interleukin-1.
Academic Article Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock.
Academic Article Interleukin-1 beta (IL-1 beta), IL-1 receptor antagonist, and TNF alpha production in whole blood.
Academic Article Monocyte cytokine production in an elderly population: effect of age and inflammation.
Academic Article In vitro production of interleukin-1 receptor antagonist in chronic renal failure, CAPD and HD.
Academic Article Interleukin-1.
Academic Article Interleukin-1 (IL-1) receptor blockade reduces endotoxin and Borrelia burgdorferi-stimulated IL-8 synthesis in human mononuclear cells.
Academic Article Coordinated antiinflammatory effects of interleukin 4: interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist.
Academic Article Modulatory in vitro effects of interleukin-1 receptor antagonist (IL-1Ra) or antisense oligonucleotide to interleukin-1 beta converting enzyme (ICE) on acute myeloid leukaemia (AML) cell growth.
Academic Article Role of interleukin-1 in the pulmonary immune response during Pseudomonas aeruginosa pneumonia.
Academic Article CD11b+/Gr-1+ immature myeloid cells mediate suppression of T cells in mice bearing tumors of IL-1beta-secreting cells.
Academic Article Interleukin-1beta-driven inflammation promotes the development and invasiveness of chemical carcinogen-induced tumors.
Academic Article Intravitreal anakinra inhibits choroidal neovascular membrane growth in a rat model.
Academic Article Inflammatory markers and the risk of Alzheimer disease: the Framingham Study.
Academic Article Interleukin-1 blockade with anakinra to prevent adverse cardiac remodeling after acute myocardial infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot study).
Academic Article Differential susceptibility to lethal endotoxaemia in mice deficient in IL-1a, IL-1? or IL-1 receptor type I.
Academic Article Interleukin-1beta and the autoinflammatory diseases.
Academic Article Interleukin-1beta modulation using a genetically engineered antibody prevents adverse cardiac remodelling following acute myocardial infarction in the mouse.
Academic Article Why not treat human cancer with interleukin-1 blockade?
Academic Article Pharmacokinetics, safety and inducible cytokine responses during a phase 1 trial of the oral histone deacetylase inhibitor ITF2357 (givinostat).
Academic Article Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases.
Academic Article Effects of interleukin-1 blockade with anakinra on adverse cardiac remodeling and heart failure after acute myocardial infarction [from the Virginia Commonwealth University-Anakinra Remodeling Trial (2) (VCU-ART2) pilot study].
Academic Article Enhanced interleukin-1 activity contributes to exercise intolerance in patients with systolic heart failure.
Concept Interleukin 1 Receptor Antagonist Protein
Academic Article Effects of interleukin-1 blockade with anakinra on aerobic exercise capacity in patients with heart failure and preserved ejection fraction (from the D-HART pilot study).
Academic Article Treating inflammation by blocking interleukin-1 in humans.
Academic Article Interleukin-1 blockade in rheumatoid arthritis and heart failure: a missed opportunity?
Academic Article Interleukin-10 in patients with ST-segment elevation myocardial infarction.
Academic Article Interleukin-18 mediates interleukin-1-induced cardiac dysfunction.
Academic Article IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans.
Academic Article A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of Interleukin-1 receptor antagonist.
Academic Article Deficient autophagy unravels the ROS paradox in chronic granulomatous disease.
Academic Article Clinical predictors of response to anakinra in patients with heart failure.
Academic Article Leukocyte activity in patients with ST-segment elevation acute myocardial infarction treated with anakinra.
Academic Article Anti-inflammatory therapies in acute coronary syndromes: is IL-1 blockade a solution?
Academic Article An anti-inflammatory property of Candida albicans ?-glucan: Induction of high levels of interleukin-1 receptor antagonist via a Dectin-1/CR3 independent mechanism.
Academic Article Comparative safety of interleukin-1 blockade with anakinra in patients with ST-segment elevation acute myocardial infarction (from the VCU-ART and VCU-ART2 pilot studies).
Academic Article Treating pulmonary silicosis by blocking interleukin 1.
Academic Article Anakinra treatment in drug-resistant Behcet's disease: a case series.
Academic Article Modulation of virus-induced innate immunity and type 1 diabetes by IL-1 blockade.
Academic Article IL-1 Receptor Antagonist Chimeric Protein: Context-Specific and Inflammation-Restricted Activation.
Academic Article Pathogenic NLRP3 Inflammasome Activity during Candida Infection Is Negatively Regulated by IL-22 via Activation of NLRC4 and IL-1Ra.
Academic Article IL-1 family members in the pathogenesis and treatment of metabolic disease: Focus on adipose tissue inflammation and insulin resistance.
Academic Article Cytokine inhibition in chronic fatigue syndrome patients: study protocol for a randomized controlled trial.
Academic Article Safety and Efficacy of Anakinra in Severe Hidradenitis Suppurativa: A Randomized Clinical Trial.
Academic Article Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome: Reanalysis of a Prior Phase III Trial.
Academic Article IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis.
Academic Article Alpha-1-anti-trypsin-Fc fusion protein ameliorates gouty arthritis by reducing release and extracellular processing of IL-1? and by the induction of endogenous IL-1Ra.
Academic Article Reduction in C-reactive protein indicates successful targeting of the IL-1/IL-6 axis resulting in improved survival in early stage multiple myeloma.
Academic Article Interleukin-1 Blockade in Acute Decompensated Heart Failure: A Randomized, Double-Blinded, Placebo-Controlled Pilot Study.
Academic Article Treating Life-Threatening Myocarditis by Blocking Interleukin-1.
Academic Article Cytokine Inhibition in Patients With Chronic Fatigue Syndrome: A Randomized Trial.
Academic Article Implication of the intestinal microbiome as a potential surrogate marker of immune responsiveness to experimental therapies in autoimmune diabetes.
Academic Article Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway.
Academic Article Treatment of Dilated Cardiomyopathy With Interleukin-1 Inhibition.
Academic Article Anakinra Therapy for Non-cancer Inflammatory Diseases.
Academic Article Corrigendum: Anakinra Therapy for Non-cancer Inflammatory Diseases.
Academic Article PASylation of IL-1 receptor antagonist (IL-1Ra) retains IL-1 blockade and extends its duration in mouse urate crystal-induced peritonitis.
Academic Article Early IL-1 receptor blockade in severe inflammatory respiratory failure complicating COVID-19.
Academic Article Interleukin 1a: a comprehensive review on the role of IL-1a in the pathogenesis and treatment of autoimmune and inflammatory diseases.
Academic Article Interleukin-1 Receptor Antagonism Abrogates Acute Pressure Overload-Induced Murine Heart Failure.
Academic Article Anakinra restores cellular proteostasis by coupling mitochondrial redox balance to autophagy.

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